IJPAR | International Journal of Pharmacy and Analytical Research

International Journal of Pharmacy and Analytical Research

ISSN: 2320_2831

Search form

Articles

  1. Development and validation of HPLC method for the estimation of Escitalopram oxalate in tablets.Download Article

    N.Ramathilagam, N.Padmaja, H.S.Amarnadh
    • Article Type: Research Article
    • View Abstract
    • Pages (1_6)
    • No of Download = 565

    Abstract

    close

    A simple, specific, robust, accurate and precise isocratic HPLC method has been developed and subsequently validated for simultaneous determination of escitalopram (ESP) in pharmaceutical dosage forms. Kromosil (250x4.6)mm 5µ with flow rate of 1ml/ min by using JASCO PU-1580 and UV/VIS JASCO UV-1570 at 238 nm. The separation was carried out using a mobile phase consisting of acetonitrile, methanol and 5mM ammonium acetate buffer (pH 3.0) in the ratio 30:20:50 respectively. The retention time for escitaloparm was found to be 5.36 minutes respectively. The correlation coefficient was found to be 0.9997 (ESP). The mean percentage recovery was found to be 101.86 respectively. The % estimation of the drugs was found near to 100 % representing the accuracy in the method. The proposed method was also validated and applied for the analysis of drugs in tablet formulation.

  2. Synthesis, antiviral and cytotoxicity activities of N-Sulphonamidomethyl benztriazole derivativesDownload Article

    Selvam.P, De Clercq E.
    • Article Type: Research Article
    • View Abstract
    • Pages (7-11)
    • No of Download = 521

    Abstract

    close

    A series of novel N-sulphonamido methyl benztriazole derivatives had been synthesized by combining benztriazole, formaldehyde and sulphonamides. Structure of synthesized compounds was elucidated by spectral analysis. Synthesized compounds were evaluated for in-vitro antiviral activity against HIV, HSV and Vaccinia viruses in cell culture. N-Sulphonamido methyl benzotriazole (BT-SN) inhibits Herpes Simplex Virus (HSV) -2 and Vaccinia virus at 34 µg/ml, respectively. HSV-1 at the concentration of 45 µg/ml. The minimum cytotoxic concentration was found to be more than 100µg/ml. So these compounds are suitable for designing newer derivatives and molecular modifications in them may help in optimizing antiviral activity.

  3. Synthesis, Anti-HIV activity and Cytotoxicity of N-Substituted Phthalimide derivativesDownload Article

    P.Selvam, C.Pannecouque , E.De Clercq
    • Article Type: Research Article
    • View Abstract
    • Pages (12-14)
    • No of Download = 416

    Abstract

    close

    A series of novel N-substituted phthalimide derivatives have been synthesized by condensation of phthalic anhydride and primary amines. Their chemical structures were assigned by means of spectral analysis (FT-IR and 1H-NMR). Synthesized compounds were screened for antiviral activity against HIV-1 and -2 replication in MT-4 cells. Cytotoxicity was also investigated in uninfected MT-4 cells. All the synthesized compounds exhibited cytotoxicity in MT-4 cells (CC50: 84-125 μg/ml).

  4. Lead toxicity due to paint and other industrial sources and contradiction in its toxicity studiesDownload Article

    Hassen A.H.Bennasir, Shanmugam sridhar
    • Article Type: Review Article
    • View Abstract
    • Pages (15-24)
    • No of Download = 428

    Abstract

    close

    Lead is one of the oldest known and most widely studied occupational and environmental toxins. Despite intensive study, there is still vigorous debate about the toxic effects of lead, both from low-level exposure in the general population owing to environmental pollution and historic use of lead in paint and plumbing and from exposure in the occupational setting. The majority of industries historically associated with high lead exposure have made dramatic advances in their control of occupational exposure. However, cases of unacceptably high exposure and even of frank lead poisoning are still seen, predominantly in the demolition and tank cleaning industries. Nevertheless, in most industries blood lead levels have declined below levels at which signs or symptoms are seen and the current focus of attention is on the subclinical effects of exposure. The significance of some of these effects for the overt health of the workers is often the subject of debate. Inevitably there is pressure to reduce lead exposure in the general population and in working environments, but any legislation must be based on a genuine scientific evaluation of the available evidences. We will discuss in this article about the various Mechanism of actions due to toxicity of the lead.

  5. Synthesis, characterization of certain new heterocyclic hybrids of pyrazoles and evaluation of their anti-inflammatory activityDownload Article

    Siddiqui Shakeel Ahmed, Sudheendra G, Shaikh Gazi, Md.Hasnuddin, Shaikh Azhar.
    • Article Type: Research Article
    • View Abstract
    • Pages (25-33)
    • No of Download = 466

    Abstract

    close

    The work presented in this article consists of synthesis, characterization and biological evaluation of substituted pyrazole derivatives. Pyrazole derivatives have been shown to have wide variety of pharmacological activities like anti-inflammatory, antidepressant and anticonvulsant. As combination of biologically active moieties into one molecule and synthesis of totally newer moieties have been the methods of research, the present study is an attempt to synthesize some novel pyrazole derivatives, incorporating various biologically active aryl / aryloxy acid derivatives, such as ibuprofen, diclofenac, aceclofenac as well as potent antibacterial quinolones, norfloxacin and ciprofloxacin. All the compounds synthesized were evaluated for their anti-inflammatory (Carrageenan induced paw oedema method) activity. The results obtained were found to be compatible with standard literature and standard drug employed. Hence, the obtained derivatives can be subjected to further clinical studies to optimize their clinical efficacy.

  6. Estimation of Pioglitazone hydrochloride in Bulk and Pharmaceutical dosage form by UV- SpectroscopyDownload Article

    M.Venkatesh, C.Sucharitha, M.Venu, Athira Shaji, K.Rajeshwer Reddy, C.Buggaiah
    • Article Type: Research Article
    • View Abstract
    • Pages (34-38)
    • No of Download = 662

    Abstract

    close

    A simple, fast and reliable Spectrophotometric method was developed for determination of Pioglitazone hydrochloride in bulk and Pharmaceutical formulation. Spectrophotometrically, Pioglitazone hydrochloride was determined by measuring the maximum absorption at 270nm. Analytical Calibration curves were linear within a concentration range from 10 to 50µg/ml. The developed method was applied to directly and easily to the analysis of the pharmaceutical tablet preparations. % R.S.D was found to be 0.51 for piosis 30 mg Tablet. The %R.S.D values for all method validation parameters were found within 2% for the developed method. The method was completely validated. The results showed that this method can be used for rapid determination of Pioglitazone hydrochloride in bulk and Pharmaceutical tablet formulation with linearity, precision, accuracy specificity.

Sign in

Registered and Approved by National Science Library (NSL),National Institute of Science Communication And Information Resources(NISCAIR),
Council of Scientific and Industrial Research,New Delhi, India"