IJPAR | International Journal of Pharmacy and Analytical Research

International Journal of Pharmacy and Analytical Research

ISSN: 2320_2831

Search form

Articles

  1. Synthesis, Characterization and Biological evaluation of substituted Pyrazole derivativesDownload Article

    Siddiqui Shakeel Ahmed, Sudheendra G, Md.Younus Ali, Md.Hasnuddin.
    • Article Type: Research Article
    • View Abstract
    • Pages (39-47)
    • No of Download = 444

    Abstract

    close

    The work presented in this article consists of synthesis, characterization and biological evaluation of substituted pyrazole derivatives. Pyrazole derivatives have been shown to have wide variety of pharmacological activities like antimicrobial, antiviral, antihistaminic, antitumor, antipyretic, anti-inflammatory, antidepressant and anticonvulsant. As combination of biologically active moieties into one molecule and synthesis of totally newer moieties have been the methods of research, we present here synthesis of some novel pyrazole derivatives incorporating various biologically active aryl/aryloxy acid derivatives such as ibuprofen, diclofenac, aceclofenac as well as potent antibacterial quinolones, norfloxacin and ciprofloxacin. All the compounds synthesized were evaluated for their antimicrobial activity.

  2. Evaluate the Disinfectant Activity of Some Commercial Preparations by Rideal -Walker Test.Download Article

    B.Ram Sarath kumar, Y.Ashok, R.Srinivasan, P.Radhika Reddy.
    • Article Type: Research Article
    • View Abstract
    • Pages (48-54)
    • No of Download = 572

    Abstract

    close

    The aim of this study was to evaluate and compare practically achieved disinfection efficacy of some locally available disinfectants on surfaces and infectious microbiological hospital waste. Three disinfectants were tested at concentrations recommended by manufacturers on rough and smooth surfaces that were contaminated experimentally by locally circulating isolates of methicillin-resistant Staphylococcus aureus, multi drug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, Enterobacter aerogenes, Pseudomonas aeruginosa strains, standard isolate of Salmonella typhi and Candida albicans. Reduction in microbial counts before and after surface disinfection was expressed as log reduction. A very heavy microbial waste load was simulated by immersing culture plates with heavy microbial growth in disinfectants. Daily, a sample of disinfectant was taken and subjected to Rideal-walker test.

  3. Analytical method Development and Validation for the estimation of Pioglitazone hydrochloride in Bulk and Tablet dosage form by UV_SpectroscopyDownload Article

    M.Venkatesh, B.Narender, D.Anusha, G.Srikanthbabu, J.Mounika, S.Laxman.
    • Article Type: Research Article
    • View Abstract
    • Pages (55-58)
    • No of Download = 630

    Abstract

    close

    This paper describes the analytical method suitable for validation of Pioglitazone hydrochloride by UV Spectrophotometric method. The method utilized UV spectroscopy and the solvent system was consists of 6 N Glacial acetic acid at wave length 270 nm. Validation experiments were performed to demonstrate Specificity, Precision, Linearity, Accuracy, ruggedness. The method was linear over the concentration range of 10-50 µg/ml. The Proposed method was simple, sensitive & reliable with good Precise, Accurate, and Reproducible and rapid for the determination of Pioglitazone. The commercial formulations are estimated without interference. Hence this method can be used for routine determination of Pioglitazone hydrochloride in bulk and their pharmaceutical dosage forms.

  4. Synthesis and Pharmacological evaluation of new Benzoxozole DerivativesDownload Article

    G.Kalyani, Raju Bathula, B.Vinatha, Perka Harathi, K.Ramadevi.
    • Article Type: Research Article
    • View Abstract
    • Pages (59-67)
    • No of Download = 431

    Abstract

    close

    Benzoxazoles1 are usually prepared by heating 2-Aminophenol with formic acids in the presence of Boric acid under reflux. Condensation of these two substances under milder conditions. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen. Benzoxazole derivatives are provided a protection against noxious UV radiation.Benzoxazole derivatives are also used in cosmotic compositions, such as for examples mainly cinnamic acid, 4-aminobenzoic acid.Benzoxazole derivatives are also used in the optical brighteners.These derivatives are used as Anticonvulsant and Neurotoxicity2 , Anti-inflammatory agents3, “Antibacterial activity”4, Cholesteryl ester transfer Protein inhibitors5, Antimicrobial activity6,7, Antifungal activity’8, Cyclooxygenase inhibitors9, hair treatment products and also used as a skin protectants.

  5. Formulation and Evaluation of Mouth Dissolving Tablets in MirtazapineDownload Article

    Anbarasu D, Nepolean R, Chandramohan K, Anandakumar A, Pitchaipillai M.
    • Article Type: Research Article
    • View Abstract
    • Pages (68-73)
    • No of Download = 411

    Abstract

    close

    The present study was undertaken with an aim to development of formulation and evaluation of mouth dissolving tablets in mirtazapine. Mirtazapine, Gelatin, Cross Caramellose Sodium, Mannitol, aerosil, magnesium stearate, aspartame, mango flavor and microcrystalline cellulose were used for the preparation of tablets. The tablets were prepared by wet granulation method and evaluated for tablets thickness, weight variation, tablet hardness, friability, and in vitro drug release. Formulation F6 can be considered as an ideal or optimized formulation for mouth dissolving tablets of mirtazapine. It can be concluded that mouth dissolving tablet of mirtazapine. Can be successfully formulated and improving its bio availability.

  6. Analytical Method Development and Validation of Dutasteride and Tamsulosin Hcl in Combination and its Stress Degradation StudiesDownload Article

    Raja Sundararajan, Christopher Vasanth Kumar, Jayaveera.
    • Article Type: Research Article
    • View Abstract
    • Pages (74-83)
    • No of Download = 1022

    Abstract

    close

    A simple,specific, sensitive,precise and reproducible Reverse Phase High Performance liquid Chromatography method has been developed for simultaneous estimation of Dutasteride and Tamsulosin Hcl. Dutasteride and Tamsulosin is Anti-hyperplasia and Anti-hypertensive drug.The determinationwas carried out byusingsymmetryC-18columnwith Methanol:0.1M Monobasic potassiumdihydrogenphosphate buffer(75:25) Adjusted the pH to 2.5 with Ortho phosporic acid as the mobile phase and with the detection wavelength of274 nmrespectively.The flow rate is 0.7 ml/min.TheRetentiontime of Dutasteride,Tamsulosin Hcl was 2.218 minand 6.599 min respectively.Linearityforthe Dutasteride and Tamsulosin Hcl were found inthe rangeof 25-75µgmand 20-60µgm respectively.The limitof quantificationforbothdrugs wasfound to be30,24µg respectively.The recoveries of Tamsulosin and Dutasteride were found to be inthe range of 99.81-99.90 %and98.00-102.00%, respectively. The proposed method was validated suitably and canbeused for routine analysis. The degradation studies indicated Dutasteride and Tamsulosin Hcl to besusceptible to neutralhydrolysis, while Dutasteride and Tamsulosin Hcl showed degradation inacid, H2O2,photolytic and inpresenceof UV radiation.The degradation productsof Dutasteride andTamsulosin Hcl inacidic and photolytic conditions were well resolved from the pure drug with significant differences in the irretention time values. This method can be successfully employed forsimultaneous quantitative analysis of Dutasteride and Tamsulosin Hcl in formulations.

Sign in

Registered and Approved by National Science Library (NSL),National Institute of Science Communication And Information Resources(NISCAIR),
Council of Scientific and Industrial Research,New Delhi, India"