IJPAR | International Journal of Pharmacy and Analytical Research

International Journal of Pharmacy and Analytical Research

ISSN: 2320_2831

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  1. Spectrophotometric Estimation of Rosuvastatin Calcium in Bulk and Pharmaceutical FormulationsDownload Article

    Chandni Saha, G.Sreelatha, Md.Nazeeruddin Ahmed.
    • Article Type: Research Article
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    • Pages (84-88)
    • No of Download = 476

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    Rosuvastatin calcium of the class statins is used for primary hyperlipidemias. It is a selective and competitive inhibitor of HMG-CoA reductase. In the present work, simple, sensitive and economic spectrophotometric method has been developed for quantitative determination of Rosuvastatin calcium. In the present spectrophotometric method Rosuvastatin calcium was dissolved in double distilled water. It exhibited an absorption maximum at 241 nm and obeyed Beer’s law in the concentration range of 5-25g/ml. The results of analysis have been validated and found to be sensitive, precise and accurate for quantitative determination of Rosuvastatin calcium in bulk drug and pharmaceutical formulations.

  2. Advance Techniques of Bilayer tablet: A ReviewDownload Article

    Pratap B.Bhalerao, M.J.Raundal, S.U.Kandharkar, P.P.Patil, M.M.Bari, Dr.S.D.Barhate.
    • Article Type: Review Article
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    • Pages (89-97)
    • No of Download = 783

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    Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablets developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (bilayer tablet) has increased in the pharmaceutical industry, promoting patient convenience and compliance. For a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. This article explains why the development and production of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as layer-separation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield, etc. Using a modified tablet press may therefore not be your best approach to producing bilayer tablet under GMP-condition. Especially when in addition high production output is required.

  3. Analytical method development and its application to extractive spectrophotometric determination of Co (II) using 1, 2-Propanedione, 1-phenyl-1-(2-hydroxybenzylideneazine) -2- oxime (PDPHBAO).Download Article

    Sushama. M. Lele , Poonam. P. Shevde, Rama. S. Lokhande.
    • Article Type: Research Article
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    • Pages (98-102)
    • No of Download = 776

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    The reagent was synthesized and characterization was carried out by FTIR, NMR, elemental analysis as well as Mass spectrometry. The synthesized reagent was then applied for the development of the analytical method for the extractive spectrophotometric determination of cobalt (II). Cobalt metal forms pale yellow coloured complex, which can be extracted in chloroform at pH 9.4 having absorption maxima at 415 nm. Beer’s law is obeyed in the concentration range 1-8.00 μg. The molar absorptivity and Sandell’s Sensitivity of the extracted species are 7.1724 X 103 Lit mol-1 cm-2 and 8.2165 X 10-3μg cm-2 respectively. The developed method is highly sensitive, selective, simple, rapid, accurate, and has been satisfactorily applied for the determination of cobalt in the synthetic mixtures, pharmaceutical samples, and alloys.

  4. Development and Validation of Uv-Spectrophotometric Method for Estimation of Abacavir Sulfate Nanoparticles.Download Article

    I.Sowkar Baig, T.Vetricheivan .
    • Article Type: Review Article
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    • Pages (103-106)
    • No of Download = 819

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    A simple, precise and accurate spectrophotometric method has been developed for the determination of Abacavir Sulfate nanoparticles. Standard Stock solution was prepared in pH 7.4 phosphate buffer and further dilution were carried out with the same. The λmax of Abacavir Sulfate nanoparticles was found to be 285 nm. The A (1%, 1cm) Value of Abacavir Sulfate nanoparticles was found to be 434. The correlation co efficient (r) was found to be 0.9999. The limit of detection (LOD) and limit of Quantification (LOQ) was found to be 0.1074 μg/ml and 0.3257 μg/ml respectively for Abacavir Sulfate nanoparticles. The result of estimation in Abacavir sulfate nanoparticles was found to be 99.62 ± 0.25%. The method was then validated statistically as per KH guidelines, which yielded good results concerning range, linearity, precision, accuracy specifically, Robustness and Ruggedness.

  5. Antibacterial activity on leaf extracts of Syzgium jambalonamDownload Article

    *M.Jeyabaskaran, B.Dhanalakshmi, K.Umamaheswar rao, T.Pranitha, V.Rajinikanth, K.Raveendra babu.
    • Article Type: Research Article
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    • Pages (107-109)
    • No of Download = 388

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    The purpose of this investigation was to extract the bioactive agents from the Methanol, Acetone extracts were examined for their activities against pathogenic microorganism (Proteus vulgaris, Staphyloccus aureus, Bacillus subtilis and E.coli). The most of the incidence of infections caused by pathogenic microorganism in our routine life and the importance of using novel synergistic drug has become important. In the present study enhanced inhibitory effects were achieved by employing solvent extracts of Syzgium jambalonam. These MIC were compared with well known antibacterial plant of Neem extract (Biological source-Azadirachta indica, Family-Meliaceae).

  6. Traditional Kashmiri Recipe “Shangri-Kahwa” as a Stimulant Drink and Effective Home Remedy for Respiratory ProblemsDownload Article

    Mudasir Khazir, Ghulamuddin Sofi, Sabha shafi, Arshid iqbal
    • Article Type: Review Article
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    • Pages (110-113)
    • No of Download = 294

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    The popular recipe “Shangri-kahwa” is an age old home remedy for respiratory and various other problems in almost whole of Kashmir. It is prepared from important spices like liquorice, clove, cinnamon, and cardamom, which have documented health benefits. Information about its use and method of preparation was obtained from group discussions held in some villages of Baramullah district of Jammu and Kashmir. People in these villages believe that Shangri-kahwa is cost effective, delicious, made from easily available ingredients and can be prepared easily at home. Being residents of this area, the authors are aware of the popularity of this magical drink used as a first line of treatment for various ailments at home, particularly during cold days. This recipe is extremely famous in these villages both as a refreshing and stimulant drink, as well as believed to be highly efficacious in respiratory illnesses. It is cost effective and highly palatable. The ingredients of Shangri-kahwa are being used extensively in Unani system of medicine and Ayurveda for almost same indications as the recipe is used. This study was carried out to highlight the effectiveness and focus the attention of the researchers towards this attractive and effective dosage form used as home remedy in Kashmir.

  7. Analytical Method Development and Validation for Simultaneous Estimation of Lamivudine and Zidovudine in Tablet Dosage form by RP-HPLCDownload Article

    M.Sravani, K.Haritha Pavani.
    • Article Type: Research Article
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    • Pages (114-120)
    • No of Download = 981

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    A new, precise, rapid, accurate RP-HPLC method was developed for the Simultaneous Estimation of Lamivudine and Zidovudine in pharmaceutical dosage forms. Chromatographic separation was achieved with mobile phase consisting of Ammonium acetate buffer pH 4.0, Acetonitrile and THF in the ratio of 60:30:10 v/v as the mobile phase with Inert sil ODS C18 (250 × 4.6 mm I.D) 5 µm, column as stationary phase at flow rate of 1 mL/min and detection wavelength of 240 nm. The retention times of Lamivudine and Zidovudine was found to be 3.793 min and 2.547 min respectively. The method was validated in terms of Linearity, Range, Accuracy, Precision, Specificity, LOD, LOQ, Robustness and system suitability according to ICH guidelines. Commercial tablet formulation was successfully analyzed using the developed method and the proposed method is applicable to routine analysis for determination of Lamivudine and Zidovudine in tablet dosage form.

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