IJPAR | International Journal of Pharmacy and Analytical Research

International Journal of Pharmacy and Analytical Research

ISSN: 2320_2831

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  1. Estimation cefixime and ornidazole simultaneous in tablet dosage form by RP-HPLC methodDownload Article

    Srikanth Choudary Pallothu, Ragoba Gnyaneshwar
    • Article Type: Research Article
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    • Pages (494- 504)
    • No of Download = 29

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    A simple, Accurate, precise method was developed for the simultaneous estimation of the Cefixime and Ornidazole in Tablet dosage form. Mobile phase containing Buffer and Degassed Methanol and Buffer in the ratio of 60:40 V/V, has been pumped through column at a flow rate of 1ml/min. Buffer used in this method was of di-sodium hydrogen phosphate and potassium dihydrogen phosphate. Temperature was maintained at 30°C. Optimized wavelength for Cefixime and Ornidazole was 254 nm. Retention time of Cefixime and Ornidazole were found to be 2.1 min and 4.9 min. %RSD of the Cefixime and Ornidazole were and found to be 0.21 and 0.26 respectively. The percentage recovery was obtained as 99.81% and 99.76% for Cefixime and Ornidazole respectively. LOD, LOQ values are obtained from regression equations.

  2. Incidence of infected open fracture wounds in level i trauma center in Saudi ArabiaDownload Article

    Wazzan Al-Juhani, Sameera Aljohani, Mohammed Benmeakel
    • Article Type: Review Article
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    • Pages (505-509)
    • No of Download = 25

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    Objectives The aim of the study is to report the incidence of positive cultures among open fractures presented to King Abdulaziz Medical City (KAMC) level I trauma center. Methods This is a prospective cross sectional study, we are reporting the incidence of positive deep swabs by taking two swab cultures from inside open fracture wounds in emergency department and operation room, then sending the swabs to our microbiology lab for cultures. Results We were able to study 36 open fractures presented to (KAMC) in a 6-month period, complete swabs were taken from 19 wounds. Negative cultures were found in 18 open fracture wounds, only one wound had a positive culture for Methicillin- resistant Staphylococcus aureus (MRSA). We were able to follow the patients for short period; none of the 18 wounds got infected. The incidence rate of contaminated wounds was 5%. The internal fixation frequency was 17 cases out of 19. One case ended up with amputation, and we treated one case conservatively with cast after irrigation and debridement. Conclusion Open fracture wounds have high risk of infection. Among our subjects, the risk was reduced by following the standard protocols in managing open fractures promptly.

  3. Brain targeting drug delivery systemDownload Article

    V. Viswanath, C. Rajaram, S. R. Fathima, C. Rupa
    • Article Type: Review Article
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    • Pages (510-520)
    • No of Download = 10

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    The prevalence rate for CNS pathology has demonstrated by approximately 1.5 billion people undergoing from disorders of CNS. Delivery of drugs to the CNS is the presence of blood brain barrier that has tendency to impair the drug distribution and it denotes the major impediment for the development of CNS drugs .In order to distribute the drugs into the CNS via passing the blood brain barrier, new emerging approaches have been developed for magnetic drugs targeting, chemical delivery system, and drug carrier system. The solid colloidal particles with a size range between 1-1000nm. In present it describes various nanotechnology based formulations such as polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions which widely used for better delivery of drugs across blood brain barrier. The net amount of delivered drug and its capability to gain access the main considering points for CNS drug development. Gradually the drug release reduced peripheral toxicity and potentiate to target at specific site and crossing the blood brain barrier are the major benefits to contributing the nanoparticles. The blood brain barrier is major challenge to deliver the drugs to CNS which limits the access of drugs to the brain substance. Strategies for drug delivery to brain involve by passing the blood brain barrier.

  4. Evaluation of khadiradikavalagraham in promoting oral hygiene among secondary and higher secondary school childrenDownload Article

    Dr. Ankush Jagota, Dr. Ankita Thakur, Dr. CharuSupriya, Dr. Jayan D, Dr. T.P. Sarasa
    • Article Type: Research Article
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    • Pages (521-542)
    • No of Download = 7

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    In current era, the oral problems are faced by people irrespective of age and gender due to the change in daily routine and food habits. Children are more prone to Oral problems as they consume food which is unhealthy. Oral problems include a number of period ontological issues leading to ill oral health. This constitutes a complex combination of different problems related to gingival, teeth and tongue hence the precise prevalence rate cannot be determined in particular age groups. Acharyas have explained the importance of Dinacharya in day today life. Here special reference about Kavalagraham has been mentioned. AcharyaVagbhata have indicated Khadiradikavalagraham for oral hygiene which contains drugs that comprises of Katu, Tiktha and KashayaRasas , possess the qualities of DantaShodhana, VranaShodhana and Ropana . Thus enables to overcome the ill oral health and maintains a good oral hygiene. Design Interventional pre-post test without control Method Present clinical trial was aimed to assess the Khadiradikavalagraham in promoting oral hygiene among secondary and higher secondary school children. Total 179 children were assessed on oral hygiene index to select the final 30, who match up with the inclusion and exclusion criteria. The duration of thetherapy was 30 days and assessment had done every month up to three months after therapy started. All subjects completed the treatment procedure. The results were statistically analyzed. Findings After 30 days of KhadiradiKavalagraham there was significant levels of reduction in symptoms like Halitosis (p<0.001), Anorexia (p<0.05), Tongue coating (p<0.001), Oral hygiene index (p<0.001), Plaque index (0.001), gingival index (p<0.001) Motivation success rate (MSR) was 53.72, which falls into the category of 50 < MSR < 70; OHMSI = 3 ; OHMSI, which implies that study was moderately successful in promoting the oral hygiene of school children. Conclusion Thepractice of KhadiradiKavalagraham was effective in promoting oral hygiene among selected secondary and higher secondary school children.

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