Preparation Of Magnetic Nanoparticles And Characterization

Abstract

Levosallbutemol,  is  a short-acting  β₂ adrenergic receptor  agonist used  in  the treatment of asthma and chronic obstructive pulmonary disease.  The prepared magnetic nanoparticles of levosalbutamol aims to deliver the drug which passes through oral route as it provides immediate or controlled release of drug when compared to other route of administration.  Formulate and characterize the formulation of levosalbutamol to minimize the side effects such as nausea, vomiting, diarrhea.  The levosalbutamolmagnetic nanoparticles was successfully prepared by using nanoprecipitation method by taking F02 to F06 formulation by using different concentration of polymer ratio. And as a polymer iron oleate is used and polyvinyl alcohol (PVA) as a stabilizer.  The prepared formulations of magnetic nanoparticles was evaluated for various parameters.  Levosalbutamolin 1:5 (F06) shows better particle shape and size, SEM study of prepared magnetic nanoparticles were within the range of (1-1000µm). There is no drug excipients interactions in FTIR and DSC.  The formulation of F06 showed good particle size with good spherical shape and uniformly distributed without any lumps. The percent drug content was found to be 76.58±0.25% in 10hrs showed anomalous mode of drug release, in F06 formulations.