Formulation and evaluation of fexofenadine oral disintegration tablets for improvising patient compliance

Abstract

One important drawback of solid dosage forms is the difficulty in swallowing or chewing in some patients particularly  pediatric  and  geriatric  patients.  Hence,  the  main  aim  of  this  study  is  to  formulate  Oral Disintegrating Tablets of  Fexofenadine to  achieve  rapid  dissolution, absorption and  further  improving the bioavailability of the drug. Dissolution test was carried out using USP rotating paddle method (apparatus 2). The stirring rate was 50 rpm. 6.8 pH phosphate buffer was used as dissolution medium (900 ml) and was maintained at 37 ± 10C. Samples of 5ml were withdrawn at pre – determined intervals (2, 4, 6, 8, 10, 15, 20, 25,30 min), filtered and replaced with 5ml of fresh dissolution medium. The collected samples were suitably dilutedwith dissolution fluid, where ever necessary and were analyzed for the Fexofenadine at 412 nm by using UV spectrophotometer. Oral disintegrating Tablets and Films of Fexofenadine were designed with a view to enhance the patient compliance and provide a quick onset of action. Hence it is very conducive to prepare the oral disintegration tablets of fexofinidine.