Fabrication and Optimization of Various Superdisintegrants to Formulate Zolpidem Tartarate Fast Dissolving Tablets

Abstract

In the general perspective, oral administration is the most popular route about 50-60% of total dosage forms are administered due to ease of ingestion, pain avoidance, versatility (to accommodate various types of drug candidates), and  most  importantly patient compliance. Difficulty in  swallowing is  also  a  common problem of  all  groups, especially the elderly and pediatrics, because of physiological changes associated with these groups. Taste of a pharmaceutical product is an important parameter governing compliance. Hence this research angled to extend towards the selection and optimization of superdisintegrants to formulate Zolpidem Tartarate fast dissolving tablets by direct compression method. The formulations F13, F14, 15 and F16 which contained increasing concentrations of combination of cross povidone with cross Croscarmellose sodium have recorded drug release 94.5%, 96.52%,99.87% and 96.38% respectively, at the end of 25 to 30 min. From the result it has been revealed that, the disintegration and dissolution of the formulation F15 contained cross povidone (5%) with cross Croscarmellose sodium (5%) was the best formulation among the all other formulations. Consequently, the formulation of the selected drug has been successfully developed as fast dissolving tablets which might significantly improve the patient compliance.