Brain targeting drug delivery system
DOI:
https://doi.org/10.61096/ijpar.v7.iss4.2018.510-520Keywords:
Brain barrier, Drug delivery, Nanotechnology, Targeted drug deliveryAbstract
The prevalence rate for CNS pathology has demonstrated by approximately 1.5 billion people undergoing from disorders of CNS. Delivery of drugs to the CNS is the presence of blood brain barrier that has tendency to impair the drug distribution and it denotes the major impediment for the development of CNS drugs .In order to distribute the drugs into the CNS via passing the blood brain barrier, new emerging approaches have been developed for magnetic drugs targeting, chemical delivery system, and drug carrier system. The solid colloidal particles with a size range between 1-1000nm. In present it describes various nanotechnology based formulations such as polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions which widely used for better delivery of drugs across blood brain barrier. The net amount of delivered drug and its capability to gain access the main considering points for CNS drug development. Gradually the drug release reduced peripheral toxicity and potentiate to target at specific site and crossing the blood brain barrier are the major benefits to contributing the nanoparticles. The blood brain barrier is major challenge to deliver the drugs to CNS which limits the access of drugs to the brain substance. Strategies for drug delivery to brain involve by passing the blood brain barrier.