Formulation research and development of floating matrix tablet of clarithromycin by using various synthetic natural polymers

Authors

  • Jyothi Department of Pharmaceutics, Dhanvanthri College of Pharmaceutical Sciences, Mahabubnagar- 509002, Telanagana, India.
  • A. Yasodha Department of Pharmaceutics, Dhanvanthri College of Pharmaceutical Sciences, Mahabubnagar- 509002, Telanagana, India.

DOI:

https://doi.org/10.61096/ijpar.v7.iss4.2018.565-578

Keywords:

Clarithromycin, HPMC, Guar gum polymers, Floating tablets.

Abstract

In the present research work Gastro retentive floating matrix formulation of Clarithromycin. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentration. gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentration of polymers of various grades of HPMC and guar gum as Polymeric substances. The formulation blend was subjected to various preformulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations HPMCK100M as polymer were retarded the drug release up to desired time period i.e., 12 hours in the concentration of 90 mg.  Whereas in low concentration the polymer was unable to produce the desired action. (F5 formulation 97.36% drug release). The formulations prepared with HPMC K15M less retarded the drug release. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed korsmeyar peppas order mechanism of drug release.

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Published

2022-09-13

How to Cite

Jyothi, & A. Yasodha. (2022). Formulation research and development of floating matrix tablet of clarithromycin by using various synthetic natural polymers. IJPAR JOURNAL, 7(4), 565–578. https://doi.org/10.61096/ijpar.v7.iss4.2018.565-578