Synthesis and antimicrobial activity of novel series of benzoxazinone containing piperazine derivatives

Authors

  • Devikasubramaniyan Department of Pharmaceutical Chemistry, Bomma Institute of pharmacy, Affiliated to JNTUH, Allipuram, Khammam – 507318, Telangana, India.
  • Rameshpetchi Rajendran Department of Pharmaceutical Chemistry, Bomma Institute of pharmacy, Affiliated to JNTUH, Allipuram, Khammam – 507318, Telangana, India.
  • Vankudoth Aruna Department of Pharmaceutical Chemistry, Bomma Institute of pharmacy, Affiliated to JNTUH, Allipuram, Khammam – 507318, Telangana, India.

Keywords:

: 4-(3-(dimethylamino-propyl)-4H-benzo[b][1,4]oxazin-3-one, Agar well diffusion method, Anti microbial activity.

Abstract

The present work is concerned with the synthesis of some new compounds com prising different benzoxazinones 4-(3-(dimethylamino-propyl)-4H-benzo[b][1,4]oxazin-3-one  containing secondary amines derivatives.. Their potential therapeutically significance tested against three strains of Gram positive bacteria (Staphylococcus aureus  Staphylococcus  epidermdisis  and  Bacillus  subtilis)  and  three  strains  of  Gram  negative  bacteria (Escherichia coli, Pseudomonas aeruginsoa and Klebsiella pneumoniae) by agar well diffusion method. The antibacterial activity of synthesized derivatives were co mpared to reference standard antibiotics Penicillin and streptomycin. The present study revealed that 4-(3-(dimethylamino-propyl)-4H-benzo[b][1,4]oxazin-3-ones possess good bactericidal activity against a panel of bacteria causing common bacterial disease s and therefore opens the possibility of finding latest clinically useful antibacterial compounds. Structures of the newly synthesized compounds were established by elemental analysis and spectral data.

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Published

2022-09-14