Design and evaluation of self micro-emulsifying drug delivery system of curcumin for solubility improvement

Authors

  • Mayank Bansal
  • Jitendra Kumar
  • Deeksha Sharma
  • Rakesh Kumar Gupta
  • Vikash Agarwal
  • Sita Kumari Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur, India.

DOI:

https://doi.org/10.61096/ijpar.v11.iss2.2022.143-154

Keywords:

Curcumin, Solubility enhancement, SMEDDS, pseudo-ternary phase diagram.

Abstract

The main purpose of the current study is to formulate a Self micro-emulsifying drug delivery system (SMEDDS) of a poorly water soluble drug curcumin to enhance solubility, dissolution rate which may improve therapeutic performance and drug loading capacity so as to develop alternative to traditional oral formulations to improve the bioavailability. The solubility of curcumin in individual microemulsion components viz. oil and surfactants was determined. The surfactants were screened for emulsification ability. Based on the solubility determinations and emulsification properties oleic acid and surfactants cremophor RH 40 and PEG 400 were selected for further study. The solubility of curcumin in different ratios of selected oil and surfactants was determined. The composition of oil:surfactants with maximum solubility for curcumin was used for SMEDDS formulation. Pseudo-ternary phase diagrams were used to evaluate the micro emulsification existence area. Formulation development and screening was done based on results obtained from phase diagrams and characteristics of resultant microemulsions. The microemulsions were evaluated for emulsion droplet size, self emulsification and phase separation, In vitro dissolution. The SMEDDS formulation showed complete release in 120 min. as compared with the plain drug, which showed a limited dissolution rate.

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Published

2022-05-02

How to Cite

Mayank Bansal, Jitendra Kumar, Deeksha Sharma, Rakesh Kumar Gupta, Vikash Agarwal, & Sita Kumari. (2022). Design and evaluation of self micro-emulsifying drug delivery system of curcumin for solubility improvement. IJPAR JOURNAL, 11(2), 143–154. https://doi.org/10.61096/ijpar.v11.iss2.2022.143-154