Formulation and evaluation of diclofenac microspheres for sustained drug delivery

Abstract

In the present work, Diclofenac sodium microspheres using Sodium alginate along with Ethylcellulose, Eudragit and HPMC as copolymers were formulated to deliver Diclofenac sodium via oral route.  Diclofenac sodium microspheres were prepared by ionotropic gelation technique by using different polymers. The prepared diclofenac microspheres were different evaluation parameters were examined for particle size, drug entrapment efficiency and in viro drug release studies. Diclofenac sodium microspheres drug release mechanism showed that the drug release from the formulations followed zero order kinetics with higuchis model of drug release