Formulation and evaluation of salbutamol sulphate sublingual tablets
DOI:
https://doi.org/10.61096/ijpar.v8.iss4.2019.472-478Keywords:
Saluabutamol Sulphate, Sublingual, First Pass Metabolism.Abstract
Salbutamol sulfate is a selective B2 bronchodilator which is used in the treatment of asthma. Conventional Salbutamol tablets available in the market are not suitable where quick onset of action is required. Salbutamol sulfate sublingual tablets were prepared by using mannitol, Aspartame, aerosil, magnesium steartate, talc and natural super disintegrants like karaya gum, locust bean gum, gellan gum by direct compression method.F6 formulation of locust bean gum was seleted as best formulation. It was shown less disintegration time of 12 seconds. It was observed that less disintegration time was observed when locust bean gum was used as natural super disintegrant, may be due to swelling at faster rate upon contact with water and elimination of lump formation after disintegration when compared with gum karaya and gellan gum. F6 formulation was found to be the best as this formulation shown less disintegration time and possessing good tabletting properties. The bioavailability of salbutamol sulfate is 44%. Bioavailability also can be increased using natural superdisintegrants. Sublingual absorption avoids first pass metabolism.