Formulation and evaluation of fast dissolving oral film of mefenamic acid

Abstract

The present study was aimed to formulate and evaluate fast dissolving oral films (FDOF) of Mefenamic acid used in the management of Rheumatoid arthritis and Dysmenorrhea. Fast dissolving oral films are meant to be dissolved in saliva and remain in oral cavity until swallowed. The fast dissolving films were prepared by solvent casting method by using HPMC as film forming polymer, due to their hydrophilic nature and palatable taste. The films were characterized by UV, FT-IR Studies. The plasticizer concentration is used for to improve good mechanical properties of the films. All the film formulations (F1-F6) were evaluated for their weight variations, thickness, surface pH, folding endurance, tensile strength, percentage elongation, in-vitro disintegration, drug content and in-vitro drug release studies. The drug excipients interactions were investigated by FT-IR, results show that there is no interaction drug and excipients. The optimized formulation F3 also showed satisfactory surface pH, drug content (99.35%), effective in vitro drug release (99.8% in 12 min), disintegration time of 12 seconds and satisfactory stability.