The unique structural and activity of the compactin as hypocholesterlemic agent, have aroused to synthesize challenging target

Authors

  • J. S. Yadav Division of Organic Chemistry-I, Natural Product Laboratory, Indian Institute of Chemical Technology, Hyderabad-500007, India.
  • Gnaneswar Duggheni Division of Organic Chemistry-I, Natural Product Laboratory, Indian Institute of Chemical Technology, Hyderabad-500007, India.

DOI:

https://doi.org/10.61096/ijpar.v5.iss1.2016.169-178

Keywords:

The synthetic strategy involves chiral propargyl alcohol from 2, 3-epoxy chloride acetylinic fragment, Ethyl chloroformate, Lindlar’s hydrogenation, Diel’s-Alder reaction.

Abstract

Hypercholesterolemia is a primary risk factor in coronary heart disease which is the major cause of deaths in the Western World. Clinical studies with lipid lowering agents have established that lowering elevated serum cholesterol levels reduces the incidence of cardiovascular mortality. In humans, more than one-half of total body cholesterol is derived from de novo synthesis. The rate-limiting step in cholesterol biosynthesis is the reduction of HMG CoA to mevalonic acid. There is the attractive possibility that compactin or some related compound might be useful as a hypocholesterlemic agent.

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Published

2016-02-22

How to Cite

J. S. Yadav, & Gnaneswar Duggheni. (2016). The unique structural and activity of the compactin as hypocholesterlemic agent, have aroused to synthesize challenging target. IJPAR JOURNAL, 5(1), 169–178. https://doi.org/10.61096/ijpar.v5.iss1.2016.169-178