Formulation and evaluation of ofloxacin ointment containing natural wound healing agent Curcuma longa

Abstract

The present investigation was aimed to formulate and evaluate the wound healing ointment. The combination of wound healing agent curcuma longa with ofloxacin is good rational, where curcuma longa produces synergistic wound healing effect with ofloxacin.  Formulations of ointments containing 0.5% ofloxacin , 0.5% ofloxacin and 5% curcuma longa, 5% curcuma longa were prepared.  To assess the efficacy of formulations viscosity, extrudability, invitro-study (Diffusion study), Stability characteristic were evaluated. The results obtained were encouraging the formulation containing ofloxacin (0.5%) with 5% of curcuma longa was found better than other formulations.