Formulation and evaluation of fast dissolving lovastatin tablets by solid dispersion

Abstract

The Fast Dissolving Tablets of Lovastatin by solid dispersion using Eudrgit RS100 were successfully prepared by direct compression method. The physiochemical evaluation results for the powdered blend of all trials pass the official limits in angle of repose, compressibility index. The prepared tablet for immediate release also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation F4 contains the average thickness of 2.75 mm average hardness of 5.6 kg/ cm2, average weight variation of ± 0.5, and friability of 0.66%. The F4 formulation of Fast Dissolving Tablets of Lovastatin showed 100% drug release within 20 mins using Eudragit RS100 as carrier whereas marketed formulation showed 100% drug release in 60 mins.