Design, synthesis, spectral analysis, antibabacterial activity of n-(3-chloro-2- oxo-4-arylazetidin-1-yl)-3 hydroxybenzofuran-2- carboxamide derivatives

Abstract

3-hydroxybenzofuran-2-carbohydrazide undergoes facile condensation with aromatic aldehydes to afford the corresponding  N-rylidene-3-hydroxybenzofuran-2-carbohydrazide in  good  yields.  Cyclo  condensation  of compounds with chloro acetyl chloride yields N-(3-chloro-2-oxo-4-arylazetidin-1-yl)-3 hydroxybenzofuran-2- carboxamide. The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacteri al activity.