Formulation and evaluation of chronomodulated drug delivery system by using metaprolol succinate

Abstract

There is an impact of circadian rhythms in the symptoms of certain diseases like cardiac diseases,  arthritis, depression, ulcer, allergic rhinitis, sleep disorders etc. The human body follows the solar/ lunar adaptations known as biological clock. The biological clock follows the main rhythm known as circadian rhythm. If the circadian rhythms dysfuncti ons it can greatly affect the function of the brain and behavior cognition. This can be improved by the chronotherapeutics approach. The objective of the present study was to develop chronomodulated tablets of metoprolol succinate, β1 - selective adrenergic receptor blocking agent. The recent interest is occur in the field of chronotherapeutics is to match the circadian rhythms of the disease for the successful treatment of disease.The impact of chronotherapeutics in the optimal treatment of diseased patient s is evaluated because in this method the treatment is done at right time with right medication at right targeted site and in the right concentration. The optimized formulation is F 9 and the percentage drug release of the optimized formulation is 98.77%.The tablets were prepared by the wet granulation method.