Formulation and Evaluation of Microspheres Containing Aceclofenac

Abstract

Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) The chemical name of aceclofenac is Glycolic
acid, [o(2,6 dichloroanilino) phenyl] acetate. Adverse effect of aceclofenac is headache, nausea, vomiting, bone
marrow problems, dizziness constipation. Elimination half-life is 4 hrs. The main objective of this research work
was to prepare hydroxyl propyl methyl cellulose and eudragit microspheres loaded with aceclofenac and invtro
relese study.In the present study, solvent evaporation method is used for preparation microspheres. The
polymers hydroxylpropyl methylcellulose and eudragit was dissolved and added to the 0.2% PVA solution and
stirred it for 2 hrs. Microspheres were spherical shape and smooth surface. Infrared spectra showed identical
peaks of drug and polymers. Drug entrapment efficiency was found to be (72.32%). In vitro release studies were
performed by using shaking flask method about (89.59 %) drug was released in 12 hrs.