Synthesis, antiviral and cytotoxicity activities of N-Sulphonamidomethyl benztriazole derivatives

Abstract

A  series  of  novel  N-sulphonamido   methyl  benztriazole   derivatives   had  been  synthesized   by  combining benztriazole,  formaldehyde  and sulphonamides.  Structure of synthesized  compounds was elucidated by spectral analysis. Synthesized  compounds  were evaluated for in-vitro antiviral activity against HIV, HSV and Vaccinia viruses in cell culture.  N-Sulphonamido  methyl benzotriazole (BT-SN) inhibits Herpes Simplex Virus (HSV) -2 and Vaccinia virus at 34 µg/ml, respectively.  HSV-1 at the concentration  of 45 µg/ml. The minimum cytotoxic concentration  was found  to be more  than  100µg/ml.    So these  compounds  are suitable  for designing  newer derivatives and molecular modifications in them may help in optimizing antiviral activity.