Synthesis, Anti-HIV activity and Cytotoxicity of N-Substituted Phthalimide derivatives

Authors

  • P. Selvam Department of Pharmaceutical chemistry, Nova College of Pharmaceutical Education and Research, Ibrahimpatnam, Vijayawada, A.P.,India.
  • C.Pannecouque Rega Institute for Medical Research, Katholieke Universiteit-Leuven. Minderbroederstraat 10, Leuven B-3000, Belgium.
  • E.De Clercq Rega Institute for Medical Research, Katholieke Universiteit-Leuven. Minderbroederstraat 10, Leuven B-3000, Belgium.

Keywords:

N-Substituted phthalimide, Antiviral activity against HIV-1 and -2

Abstract

A series  of  novel  N-substituted  phthalimide  derivatives  have  been  synthesized  by condensation  of  phthalic anhydride  and primary amines. Their chemical  structures  were assigned by means of spectral  analysis (FT-IR and 1H-NMR). Synthesized  compounds  were screened for antiviral activity against HIV-1 and -2 replication in MT-4  cells.  Cytotoxicity  was  also  investigated  in  uninfected  MT-4  cells.    All  the  synthesized  compounds exhibited cytotoxicity in MT-4 cells (CC50: 84-125 μg/ml).

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Published

2013-02-14

Issue

Vol. 2 No. 1 (2013): 2013 Volume - 2 Issue - 1

Section

Articles