A Comprehensive Review On Analytical Methods For The Quantification Of Favipiravir In The Drug Product, Drug Substance And In Biological Samples

Abstract

Advanced Pharmaceutical analysis plays an important role in the quantitative estimation of drugs in the drug formulations and in biological samples. The Present review highlights the different methods used for the estimation of Favipiravir. Favipiravir is one of the drug used in the management of COVID-19 infection. Favipiravir acts by selectively inhibiting the RNA dependent RNA polymerase, an enzyme required for RNA viral replication inside human cells. It shows a broad spectrum of activity against different RNA viruses including influenza virus. The current review article provides the data for the quantification of favipiravir by using UV, HPLC and LCMS/MS methods. In this review the estimation of favipiravir in the drug substance and product can be done by using HPLC methods and in the plasma sample the drug quantification can be done by using LC MS/MS methods. This data can be used for the verification of listed methods briefly for the development of new methods for the research and development