A Review On Non Aqueous Titrations Used In Assay Of Various Drugs

Abstract

Various titrimetric methods are available for estimation of acids and bases, except very weak acids and bases which can only be estimated by non-aqueous methods of titration or potentiometry. Non aqueous means of titrimetric analysis involves the conversion of weak acid to strong acid or weak base to strong base by excerting the differentiating effect when dissolved in basic or acidic solvents.The Non aqueous titration method was carried out using 0.1 N Perchloric acid.The end point of the titrations is determined via non aqueous indicator solutions such as crystal violet, nile blue A, 1-Naptholbenzein, oracet blue B.