Isolation and Characterization of Fenugreek Seed Mucilage, A Natural Mucoadhesive Polymer.

Abstract

This study focuses on isolating and characterising fenugreek seed mucilage, a natural mucoadhesive polymer derived from Trigonella foenum-graecum. The extraction process of mucilage, which involved using deionized water followed by precipitation with acetone, demonstrated high efficiency, yielding 31.78% mucilage from the seeds. Characterization of the mucilage confirmed the presence of carbohydrates and mucilaginous properties, with an ash value indicating high purity. The mucilage displayed favourable micromeritic properties, such as good flowability and low moisture content, which are essential for pharmaceutical applications. Its pH and swelling index suggest compatibility with gastrointestinal environments. Comparative analysis revealed that fenugreek seed mucilage has mucoadhesive strength similar to Carbopol 934 P and significantly higher than sodium alginate, making it a promising candidate for use in drug delivery systems.