A review on transethosomal drug delivery system

Abstract

The skin has a surface area of 1.8 m², and is essential for drug administration because of its enormous surface area for drug dispersion. However, drugs have limitations when it comes to low bioavailability, short residence time, systemic adverse effects, poor skin penetration, and reaching target areas.  The goal of novel transdermal medication delivery strategies, including vesicular nano-carrier delivery systems, is to decrease dosage frequency, improve patient compliance, and minimize side effects. Although transdermal medicine distribution is a useful technique, many pharmaceuticals are unable to pass through the main barrier, the stratum corneum. Ethosomes, transferosomes, and transethosomes (TEs) are examples of ultra-deformable vesicles (UDVs) that have been designed to get over this obstacle and deliver medications to the intended location. Transethosomes show promise for transdermal drug delivery because of its ability to accommodate drug molecules with a broad range of solubility because to their lipophilic and hydrophilic areas. Because TEs contain larger amounts of phospholipid, edge activator, and ethanol, they have superior penetration through the stratum corneum. Transethosomes improve the solubility and stability of drugs, which boosts their effectiveness. By administering the medication in a semisolid dosage form, patient compliance is improved.