Formulation and evaluation of baclofen nanogel by using synthetic polymer

Abstract

Nanogels, highly cross-linked nano-sized hydrogel systems, offer significant potential as drug delivery vehicles due to their unique properties such as high water content, biocompatibility, and the ability to encapsulate both hydrophilic and hydrophobic drugs. This study focuses on the formulation and evaluation of Baclofen nanogel using synthetic polymers. The nanogels were prepared via the emulsion solvent diffusion method, incorporating Baclofen hydrochloride with Eudragit S-100 and Carbopol-940. The formulations were characterized by particle size, zeta potential, pH, viscosity, spreadability, drug content, and in vitro drug release. The optimized formulation (F9) demonstrated a mean particle size of 449 nm and a zeta potential of 13.3 mV, indicating good stability. The pH of the formulations ranged between 6.40 to 6.94, suitable for topical application. Drug content analysis showed formulation F9 had the highest drug content at 87.06%. In vitro release studies using Franz Diffusion Cell revealed that formulation F9 had the highest cumulative drug release of 83.62% over 24 hours, following zero-order release kinetics. The study concluded that Baclofen nanogel, prepared using synthetic polymers, is effective for transdermal drug delivery, offering sustained release and enhanced bioavailability. The nanogel formulation provides a promising approach for treating muscle spasms and related conditions, reducing the frequency of administration and potential side effects.