To control the para-Hydroxybenzoic Acid during the synthesis of Sodium Methyl Paraben Preservative

To control the para-Hydroxybenzoic Acid during the synthesis of Sodium Methyl Paraben Preservative

Authors

  • Chirag Dhamsania Venu Health Care, Block no.152,153/p/1,155/1, B/H Umiya Way Bridge, Nr. Nayara Petrol Pump, Kadi road, Dhanot, Chhatral (N.G) – 382729, Gujarat, India
  • Sanghadiya Divyang G Venu Health Care, Block no.152,153/p/1,155/1, B/H Umiya Way Bridge, Nr. Nayara Petrol Pump, Kadi road, Dhanot, Chhatral (N.G) – 382729, Gujarat, India

DOI:

https://doi.org/10.61096/ijpar.v13.iss4.2024.705-708

Keywords:

Overview to control the para-Hydroxybenzoic Acid during the synthesis of Sodium Methyl Paraben, Esterification, Neutralization, Hydrolysis

Abstract

Sodium Methyl Paraben (SMP) is the sodium salt of Methyl Paraben. Para-Hydroxybenzoic acid is most common Degradation impurity of Sodium Methyl Paraben. There are several mechanisms involves the formation of Para-Hydroxybenzoic Acid (PHBA) as an impurity during Sodium Methyl Paraben (SMP) synthesis. Mainly Parent paraben readily undergo base-catalyzed hydrolysis of the ester bond, forming PHBA. Solvent may affect the formation of PHBA, mainly the role of Methanol.

 

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Published

2024-11-23

How to Cite

Chirag Dhamsania, & Sanghadiya Divyang G. (2024). To control the para-Hydroxybenzoic Acid during the synthesis of Sodium Methyl Paraben Preservative. International Journal of Pharmacy and Analytical Research, 13(4), 705–708. https://doi.org/10.61096/ijpar.v13.iss4.2024.705-708

Issue

Vol. 13 No. 4 (2024): 2024 Volume - 13 Issue - 4

Section

Articles