Design and evaluation of microspheres incorporated buccal gel of antihypertensive agent benazepril
Keywords:Benazepril, ACE inhibitor, mucoadhesive microspheres, buccal gel
The objective of current research is to formulate benazapril microsphere incorporated buccal gel and evaluated. Mucoadhesive microspheres of benazepril prepared using eudragit EPO polymer. Based on maximum drug content (98.94%) and entrapment efficiency (98.79%) exhibited by F10 formulation of benazepril microsphere was chosen as optimised formulation for incorporation into buccal gel of benazepril. The formulation F10 selected was employed for preparation of buccal gel using various polymers like carbopol 934P, HPMC E50LV, poloxamer 407 by mechanical stirring process to develop mucoadhesive buccal gel containing benazepril microspheres. A total of nine formulations were prepared followed by evaluation for pH, viscosity, percent drug content, drug release studies, bioadhesion and accelerated stability studies. The formulation BG6 was chosen as optimized one with maximum release of drug i.e. 99.54% in comparison to pure drug with 38.41% release and subjected to FTIR, SEM and stability studies. The formulation was stable. From all the evaluation studies conducted buccal gel formulated from mucoadhesive microspheres showed that it has potential to deliver benazepril in controlled manner over prolonged time period for buccal use.