IJPAR JOURNAL https://ijpar.com/ijpar ijpar Prof.Dr.N.Sriram en-US IJPAR JOURNAL 2320-2831 Advanced Method Development And Validation For Analyzing Cefixime Trihydrate And Levofloxacin Hemihydrate In Tablet Formulations Using First-Order Derivatives https://ijpar.com/ijpar/article/view/774 <p>The research paper is concerned with the Analyzing Cefixime Trihydrate and Levofloxacin Hemihydrate in Tablet Formulations Using First-Order Derivatives presents a novel approach to pharmaceutical analysis through derivative spectrophotometry. This method involves transforming standard absorption spectra into first-order derivative spectra, enhancing the precision and resolution of substance identification. By analyzing the rate of absorbance change with wavelength(CEFI 297.2 nm &amp; LEVO 288.6 nm), specific spectral features can be pinpointed, facilitating accurate quantification and characterization of substances. Utilizing a UV-visible spectrophotometer with advanced software, the study focused on the analysis of Cefixime Trihydrate and Levofloxacin Hemihydrate, common pharmaceutical compounds. The validation process adhered to international guidelines, ensuring the method's reliability and accuracy (CEFI 100.4&nbsp; ± 0.94 &amp; LEVO 100.4&nbsp; ± 0.82). Calibration curves exhibited linearity over a defined concentration range for both compounds, validating the method's suitability for quantitative analysis. Overall, this study contributes to the advancement of analytical techniques for pharmaceutical quality control and research, emphasizing the pivotal role of derivative spectrophotometry in modern analytical practices.</p> N. Elavarasan Geolin Justin Babu J. Ansal Shakina V.L. Saranya Copyright (c) 2024 2024-07-15 2024-07-15 13 3 289 296 Therapeutic Potential of Heeraka Bhasma (Incinerated Diamond ash): A review through Classical and Contemporary literature. https://ijpar.com/ijpar/article/view/775 <p>The ancient Indian alchemical tradition of Rasashastra encompasses a diverse literature on the therapeutic application of metals, minerals, and gemstones. This tradition later integrated into Ayurveda, the indigenous medical system of India, forming a significant branch thereof. Within Rasashastra's classical texts, <em>Heeraka</em> (Diamond) is categorized under <em>Ratna Varga </em>(Precious gemstones classification), alongside other precious and semiprecious gemstones. Notably, <em>Heeraka Bhasma</em>, the incinerated ash of diamond, finds mention for treating internal abscesses, tumors, angina pectoris, and tuberculosis. Reviewing over 30 classical texts reveals various pharmaceutical procedures like <em>Shodhana</em>(Purification) and <em>Marana</em>(Process of preparing Bhasma), enhancing <em>Heeraka's</em> therapeutic potential. Common purification methods include <em>Nirvapa</em>(Hearing and Quenching) and <em>Swedana</em>(Boiling), while <em>Gajaputa</em>(Amount of Heat) is the commonest puta given&nbsp; for <em>Bhasma</em>(Incinerated Ash) preparation, often employing Karpasa Mula and 3-year-old <em>Nagvalli swarasa</em> as media. This review aims to comprehensively explore diamond's processing techniques and therapeutic attributes as described in classical literature and contemporary research.</p> Rakshitha Shetty G. Priyadarshini R. Koirala K.S. Sakhitha S. Kumar Copyright (c) 2024 2024-07-15 2024-07-15 13 3 297 308 Synthesis, Characterization and Biological evaluation of New Schiff’s Base Derivatives https://ijpar.com/ijpar/article/view/776 <p>This manuscript presents the synthesis, characterization, and biological evaluation of novel Schiff’s base derivatives derived from aromatic aldehydes and amino acids. Schiff bases, known for their biological relevance and stability when linked to aryl groups, were synthesized using a condensation reaction facilitated by mildly acidic conditions to ensure optimal yields without compromising the nucleophilicity of the amines. The synthesized compounds were rigorously characterized using melting point determination, thin-layer chromatography (TLC), and infrared spectroscopy (IR). Their biological efficacy was assessed through in vitro antibacterial and antifungal assays, demonstrating considerable activity against common pathogenic strains such as Escherichia coli, Bacillus subtilis, and Candida albicans. The compounds exhibited a range of activities, with some showing comparable efficacy to standard antibiotics and antifungals. These findings suggest that Schiff’s bases could be potent candidates for drug development, offering a scaffold for further chemical enhancement and therapeutic application.</p> M. Mohanapriya R. Manivannan C. Praveen Kumar T. Ranjith C. Udhaya Copyright (c) 2024 2024-07-16 2024-07-16 13 3 309 320 A review on analytical method development and validation of pantaprazole in bulk and tablet formulation by using Uv- spectrophotometry https://ijpar.com/ijpar/article/view/779 <p>Pantoprazole (Protonix) is an irreversible proton pump inhibitor (PPI) that reduces gastric acid secretion. in conjunction with a pair of antimicrobial medicines, most frequently amoxicillin, clarithromycin, or metronidazole. Analysis can be done by various methods. Most commonly used solvents are HCl, NaOH, Methanol, Water. Various parameters are collected including LOD, LOQ, Correlation Coefficient and linearity range, accuracy, Ruggedness. &nbsp;&nbsp;</p> A. Raja Reddy S. UdayKiran Sabitha Sabu T. Rama Rao Copyright (c) 2024 2024-07-22 2024-07-22 13 3 321 326 Development and Validation of Simple and Precise UV Spectroscopy Method for Quantifying Baicalein & Berberine in Bulk and Formulated Products https://ijpar.com/ijpar/article/view/781 <p>A simple, precise, and cost-effective UV-visible spectrophotometric method was developed and validated for the simultaneous estimation of baicalein and berberine in bulk and formulations, in accordance with ICH Q2 (R1) guidelines. Calibration standards of baicalein and berberine were prepared, and calibration curves of concentration versus absorbance were plotted. Various analytical method validation parameters such as linearity, accuracy, precision, robustness, ruggedness, limit of detection, and limit of quantitation were calculated. The maximum wavelengths for baicalein and berberine were found to be 274 nm and 344 nm, respectively. The correlation coefficients over the concentration ranges of 0.5-8 μg/ml and 5-30 μg/ml were 0.998 and 0.999 for baicalein and berberine, respectively. The developed UV method demonstrated high precision, accuracy, and sensitivity, with % RSD less than 2. This validated UV-visible method can be efficiently used for the individual and simultaneous estimation of baicalein and berberine in bulk and formulations.</p> Vijendra Singh Chauhan Krishnamoorthy B Jitin Kumar Shashikant Himanshu Sharma Pradeep Saini Copyright (c) 2024 2024-07-26 2024-07-26 13 3 327 334