International Journal of Pharmacy and Analytical Research

A Review on: Dragon fruit- based herbal toothpaste

Mon, 13 Oct 2025 00:00:00 +0000

Dragon fruit (Hylocereus undatus) is rich in fiber, vitamin C, antioxidants, and bioactive Compoundsthat contribute to oral health. The fiber content assists in mechanical cleaning by Binding to plaque and food debris, thereby preventing gum disease. Vitamin C acts as a Powerful antioxidantthat strengthens gum tissue and supports healing of the oral mucosa. Herbal toothpaste formulations containing dragon fruit, along with other natural ingredients, can help combat common oral problems such as dental caries, gingivitis, halitosis, calculus Formation, enamel erosion, and dentin hypersensitivity. These formulations are designed to Deliver maximum bioavailability of active constituents while providing effective cleaning. Polishing, and protection of teeth. Compared to chemical-based toothpastes, herbal Toothpastes offer similar or better efficacy with fewerside effects, making them a safer and Eco-friendly alternative for maintaining oral hygiene and promoting overall oral health.

Focus: Study the potential and role of dragon fruit in herbal toothpaste formulation.

Purpose: To review its properties, benefits, and formulation scope for improving oral hygiene and promoting natural dental care.

Molecular Docking Analysis of Novel JAK-2 Inhibitors for Therapy of Myeloproliferative Neoplasms

Indira Rani Nerella, G. Divya, Siva Jyothi Buggana — Thu, 16 Oct 2025 00:00:00 +0000

Background and Objectives: Januskinase-2 (JAK2) is an intracellular, non-receptor tyrosine kinase belonging to the family of Janus kinase that also includes JAK1, JAK3 and TYK2.The recent discovery of JAK2's acquired point mutation V617F led to greater understanding its oncogenic role in Myeloproliferative tumors (MPN’S). At 617 position phenylalanine amino acid was replaced by valine due to mutation. Therefore, aiming abnormal JAK-2 to prevent its essential activation will be an optimistic alterative option in the treatment of Myeloproliferative tumors.

Methods: In this current study, using computational methods we have designed 114 novel Quinazoline JAK2 –inhibitors and evaluated them for interaction with the enzyme JAK2 through insilico analysis like prediction of pharmacokinetics & Molecular docking studies.

Results: Among the designed 114 novel Quinazoline JAK2 – inhibitors 98 compounds were shown good activity with better dock scores and good ADMET properties with no Lipinski rule violation.

Conclusion: Our present study concludes that the designed novel Quinazoline JAK2 –inhibitors are having potent anticancer activity.

Review on Antiasthamatic Herbs

Thorat Priyanka Fulchand, Thorat Akash Fulchand — Fri, 17 Oct 2025 00:00:00 +0000

Asthma is a disease of the airways which is chronic in nature. The inflammation of the airways results in increased contractibility of the smooth muscles which are surrounding the airways. As a result of this, the airways are narrowed and finally it results in wheezing. The causes of asthma are both environmental and genetic. Epigenetic as well as the changes occurring in the environment cause asthma. Allergens, air pollution, high ozone levels, traffic pollution, cockroaches, dust mites, animal dander, mould and smoking are the factors that result in asthma. Asthma is essentially characterized by the restriction of obstruction tracheal muscle. Herbs are used as a natural remedy for the management of asthma. The treatment of asthma is mainly focused on the strengthening of the health of the lungs, nervous and immune systems. This generally requires long time therapy and more over the people has been realized serious adverse effects of the synthetic drugs which are used in the management of asthma. As a result, the world has started exploring the herbs as an agent of asthma therapy. Plants which are comparatively economical, easily available, and relatively free from the hazardous side effects are usually selected.

From ancient times, Ayurvedic science has explored, analysed and documented the medicinally important plants through assessment of their multiple modes of therapeutic action. Natural products have been an important resource for maintaining life for ages, as evident from Indian Ayurvedic literatures like Charak and Sushruta Samhita. Current synthetic drugs hold no promise incomplete healing of these disorders. In contrast to them, many target specific herbal alternatives have been recognized due to properties like bronchodilator, mast cell stabilization, anti-inflammatory, anti-allergic, immunomodulatory as well as inhibitory action on mediators of inflammation (leukotriene’s, cyclooxygenase, cytokines etc.)