Preparation and evaluation of a new gel formulation of acetominophene
DOI:
https://doi.org/10.61096/ijpar.v7.iss4.2018.618-621Keywords:
Acetominophene, Carbomer, propylene glycol, Aspartame, Sunset yellow FCF, Screening, Antipyretic activity.Abstract
The occurrence of oral semisolid dosage form in pharmaceutical field is rare. Oral gels are preparations designed to produce a greater patient compliance especially in pediatrics due to its palatability and elegant in appearance. Acetaminophen, a Para aminophenol derivative is a potent analgesic and antipyretic with weak anti-inflammatory activity.The aim of this study is based on the preparation of the gel form of the acetominophene and evaluate the screening effects of the newly formulated gel by using the animal model.
Objective
The present study is focused to formulate the acetominophene gel and study its properties and evaluate its screening effect on rabbits. The formulated gel was studied for its Drug content and its stability at room temperature for stipulated number of days.
Methods
The various excipients used for the formulation of the gel was added to proportion and batch sizes of100 ml was prepared .The gel considered for this formulation was carbomer. The carbomer is hydrophilic and produces spar kling clear gel when? neutralised with alkali. Carbomer disperses in water to form acidic colloidal solutions of low viscosity which when neutralised with alkali to produce high viscosity gels. So, carbomer was considered for our formulation.
Results
The properties of the newly formulated drug had the properties of the gel and the drug content and the stability of the drug showed significant results .The screening studies on the animal model yielded desired results
Conclusion
The study confirmed the properties of the acetominophene in the newly formulated gel and its effect for its anti pyretic activity is also achieved for the gel formulated drug.
