Formulation and evaluation of nanosuspension of etoricoxib for solubility enhancement

Authors

  • Yadav Shivangi Department of Pharmaceutics, Swami Vivekanand College of Pharmacy, Indore (M.P) India.
  • Agrawal Shikha Department of Pharmaceutics, Swami Vivekanand College of Pharmacy, Indore (M.P) India.

DOI:

https://doi.org/10.61096/ijpar.v8.iss3.2019.308-319

Keywords:

Nanosuspension technology, Etoricoxib, Stabilizers, High Pressure Homogenization. Solubility enhancement.

Abstract

The aim of the present study is to increase the solubility as well as dissolution rate of Etoricoxib drug by the preparation of nanosuspension of Etoricoxib by using different stabilizer namely Pvpk 30, Tween 80, PEG 6000, and PVA. This approach of delivering drug is mostly suitable for lipophilic drug and poorly or water insoluble drugs. Etoricoxib is a lipophilic drug that is practically insoluble in water and exhibit an excessively slow dissolution rate in class II compound in biopharmaceutics classification system Thenanosuspension of etoricoxib were prepared by High Pressure Homogenization (HPH) technique by using different concentration of stabilizers. The prepared Nano suspensions were evaluated for partical size, solubility studies, drug content, Dissolution study and Zeta potential studies. The saturated solubility studies and In-vitro dissolution studies as observes that the increase in solubility of drug and enhanced dissolution rate in nano suspension as compared to pure drug. The Formulation F2 and F8 is considered as best formulation as it has shown highest drug release in short time. Our studies showed that the solubility of the drug can be significantly enhanced with increase in the stabilizers concentration there is increase in the solubility resulting in enhanced dissolution rate.

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Published

2022-09-12

How to Cite

Yadav Shivangi, & Agrawal Shikha. (2022). Formulation and evaluation of nanosuspension of etoricoxib for solubility enhancement. IJPAR JOURNAL, 8(3), 308–319. https://doi.org/10.61096/ijpar.v8.iss3.2019.308-319