Design & in vitro evaluation of floating microspheres using misoprostol

Abstract

The present research was aimed to prepare Misoprostol floating microspheres for sustained release using polymers such as sodium alginate and Hydroxy propyl methyl cellulose (HPMC K4M) by ionotropic gelation method. Drug and excipient compatibility studies were carried out by FT-IR and no interaction was observed. The prepared microspheres were evaluated for the Percent drug content, entrapment efficiency and In-vitro dissolution studies. Different formulations were prepared with different concentrations of polymers, among all the formulations F12 was selected as optimized formulation based on the micromeretic and physico chemical parameters including drug release studies. In vitro release study of formulation F12 showed 99.11% drug release after 12 h in a controlled manner, which is desired for disease like peptic ulcer. In vitro release profiles from optimized formulation F12 were applied on various kinetic models. The best fit with the highest correlation coefficient was observed in zero order and Higuchi model, indicating diffusion controlled principle. The marketed product IR tablet shows the drug release of 95.23% within 1 h. The results obtained from evaluation and performance study of different types of Misoprostol microspheres that system may be useful to achieve a controlled drug release profile may help to reduce the dose of drug, dosing frequency and improve patient compliance when compared with marketed product