Formulation and evaluation of liposomal drug delivery system of decitabine

Abstract

The drug release from Liposomes depends on many factors including the composition of Liposomes, the type of drug encapsulated and nature of the cell. Once it is released a drug that normally crosses the membrane of a ce ll will enter the cell, other drugs will not enter.

Decitabine is a short biological half-life. This study aimed at formulating and evaluating liposomal formulation of Decitabine in order to enhance its bioavailability. In evaluation study the effect of th e varying composition of lipids on the properties such as encapsulation efficiency, particle size and drug release were studied. Phase transition study was carried out to confirm the complete interaction of Decitabine with bilayer structure of liposome. Moreover, the  release of the  drug was also  modified and  extended over  a  period of 8  h  in  all formulations. F1  emerged as  the  most satisfactory formulation in  so  far  as  its properties were concerned. Further,  release  of  the  drug  from  the  most  satisfactory  for mulation  (F1)  was  evaluated  through  dialysis membrane to get the idea of drug release. The mechanism of dug release was governed by Peppas model.