Simultaneous UV-spectrophotometric estimation of ibuprofen and moxifloxacin in pH 6.8 phosphate buffer

Abstract

Rapid development of research in the field of periodontal drug delivery poses challenges in developing new analytical
methods to estimate combination of drugs used to treat infections. Preferably, the anti-inflammatory agent is a nonsteroidal anti-inflammatory drug (NSAID), such as ibuprofen should be employed in subgingival infections along other
anti-microbial agents such as moxifloxacin. The aim of the present investigation is to develop a precise and rapid
simultaneous estimation of ibuprofen and moxifloxacin using a UV spectroscopic method in pH 6.8 phosphate buffer.
Ibuprofen and moxifloxacin showed absorbance maxima at 224.5 nm and 287 nm in 6.8 pH phosphate buffer respectively.
The validation parameters proved that the developed method could be employed successfully for simultaneous routine
determination of these drugs in formulations such as in situ gels intended for periodontal infections.