Development and validation of septrophotometricmethods for the estimation of rasagiline in tablet doage form

Abstract

Two simple and sensitive spectrophotometric methods (A and B) for the determination of Rasagiline mesylate in tablet dosage form are described. In method A – UV Spectroscopic method, Distilled Water was used as solvent and shows absorption maximum at 265 nm. In the method B – UV Spectroscopic method, 0.2 N Methanolic Hydrochloric acids was used as solvent and shows absorption maximum at 211 nm. The Beer’s Law range for method A is 20 –160 µg/ml and 4 – 20 µg/ml for method B. The linear regression for method A and B are found to be 0.9999 and 0.9998 respectively. When tablet dosage forms where analysed, the results obtained by the proposed methods are in good agreement with the labelled amount and the results were validated statistically.