Formulation and evaluation of valsartan pulsincap drug delivery system

Abstract

The purpose of study was to formulate and evaluate Pulsincap drug delivery system of Valsartan for time release. Several
functions such as Blood pressure (BP), heart rate, stroke volume, cardiac output, blood flow of the cardiovascular system
are subject to circadian rhythms. For instance, capillary resistance and vascular reactivity are higher in the morning and
decrease later in the day. Formulation with (programmable delivery) PDDS make it possible to delivery drug at specific
time in chronopharmacokinetic studies. Valsartan prepared with a view to release the Valsartan around 5am with a lag
time of 8hr after administration. The basic design consists of an insoluble hard gelatin capsule body filled with physical
mixture of Valsartan granules and sealed with HPMC K100. We found that the type and amount of polymers influenced
the drug release. Valsartan granules are prepared with different ratios of polymers like HPMC and/or EC by geometric
mixing method. The lag time was dependent on the compassion of these polymers. Granules are filled in the formaldehyde
treated insoluble capsule body and plugged with the HPMCK100. The finished dosage forms were subjected to various
QC tests like uniformity of weight, drug content and in-vitro release. Promising results indicated Val F7 shows 99.58% of
drug released with 8 hrs lag time. Thus this approach can provide a useful means for timed release of Valsartan and may
be helpful for patients with morning surg.