Formulation and evaluation of pulsatile drug delivery system using meloxicam

Abstract

In the current research work, meloxicam is taken as a model drug. Meloxicam is non steroidal anti inflammatory drug which
is used in the treatment of rheumatoid arthritis in children. This research work deals with the preparation of eroding or
soluble barrier layer surrounding the core tablet and the drug release is time dependent. The system releases the drug after a
predetermined lag time of 8 h and thus the dosage forms can be taken at bedtime so that the content will be released in the
morning hours, when the symptoms are more prominent.
The optimized form of MELOXICAM with superdisintegrants like Xanthum gum and Guar gum in concentration (0.3-0.1g)
may be attributed to rapid release of tablet. It was observed that disintegration time of tablet decrease with increased in
concentration of these super disintegrants. The hardness of the pressed coated tablet was observed as 6.8 (Kg/cm2
) whereas
friability was less than 1% which indicated that tablet had good mechanical resistance. Drug content was found to be high
(>98.14%) and uniform in all tablet formulations and % drug release was found to be 99.65% after 8 hours. The order of drug
release from matrix system was described by using zero order kinetics. On the basis of these evaluation parameters it was
found that P3F7 shows consistent release of drug after the predetermined lag time and therefore it was optimized as a
promising approach of meloxicam as Pulsatile Drug Delivery System.