Formulation development and invitro characterization of oro dispersible tablets of Celecoxib

Abstract

In this study was to prepare fast disintegrating tablets of Celecoxib by using super disintegrants in varying proportions. The tablets were prepared by using various super disintegrants like crospovidone, cros carmellose sodium, explotab, magnesium  sterate,  talc  and  microcrystalline cellulose.  The  tablets  were  evaluated  for  weight  variation,  hardness, friability, wetting time, water absorption ratio, and disintegration time (DT) and dissolution study.  From the results obtained, it can be concluded that the prepared tablets were shown good pre & post compression parameters and they passed all  the  quality control evaluation parameters as  per  I.P  limits.  Among all  the  formulations F3  formulation containing crospovidone as super disintegrant, showed maximum % drug release i.e., 99.8 % in 6 min hence it is considered as optimized formulation.