SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW BENZOXOZOLE DERIVATIVES

Abstract

Benzoxazoles1    are   usually   prepared   by heating 2-Aminophenol  with formic acids in the presence  of  Boric acid  under  reflux.  Condensation   of  these  two  substances  under  milder  conditions.   Being  a  heterocyclic compound,  benzoxazole  finds use in research as a starting material for the synthesis of larger, usually bioactive structures.   It  is  found   within   the  chemical   structures   of  pharmaceutical   drugs   such   as  flunoxaprofen. Benzoxazole  derivatives  are provided a protection  against noxious UV radiation.Benzoxazole   derivatives   are also   used   in   cosmotic   compositions,    such   as   for   examples   mainly   cinnamic   acid,   4-aminobenzoic acid.Benzoxazole    derivatives   are   also   used   in   the   optical   brighteners.These    derivatives   are   used   as Anticonvulsant   and  Neurotoxicity2   ,  Anti-inflammatory  agents3,  “Antibacterial   activity”4,  Cholesteryl  ester transfer  Protein  inhibitors5,  Antimicrobial  activity6,7,  Antifungal  activity’8,  Cyclooxygenase   inhibitors9,  hair treatment  products  and  also  used  as a  skin  protectants.