Formulation development and characterization of voriconazole nanoparticles

Abstract

Nanoparticles represent a promising drug delivery system of controlled and targeted drug release. They are specially designed to release the drug in the vicinity of target tissue. The aim of this study was to prepare and evaluate Carbopol p934 nanoparticles containing Voriconazole in different drug to polymer ratio. SEM indicated that nanoparticles have a discrete spherical structure. FT-IR studies indicated that there was no chemical interaction between drug and polymer and stability of drug. The in vitro release behavior from all the drug loaded batches was found to be first order release and provided sustained release over a period of 12 h. The developed formulation overcome and alleviates the drawbacks and limitations of Voriconazole sustained release formulations and could possibility be advantageous in terms of increased bioavailability of Voriconazole