A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ASPIRIN AND PRASUGREL IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM

A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ASPIRIN AND PRASUGREL IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM

Authors

  • Udutha Kiran Yadav Department Of Pharmaceutical Analysis, Princeton College Of Pharmacy In Narapally, Ghatkesar, Telangana.
  • Sunitha Ch Department Of Pharmaceutical Analysis, Princeton College Of Pharmacy In Narapally, Ghatkesar, Telangana.
  • Harikiran l Department Of Pharmaceutical Analysis, Princeton College Of Pharmacy In Narapally, Ghatkesar, Telangana.

Keywords:

Aspirin, Prasugrel, RP-HPLC, validation.

Abstract

A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Aspirin and Prasugrel in its pure form as well as in tablet dosage form. Chromatography was carried out on a Symmetry C18 (4.6 x 150mm, 5µm) column using a mixture of Acetonitrile: Water (35:65) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 238nm. The retention time of the Aspirin and Prasugrel was 2.456, 4.312 ±0.02min respectively. The method produce linear responses in the concentration range of 50-250µg/ml of Aspirin and 5-25µg/ml of Prasugrel. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

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Published

2025-10-29

How to Cite

Udutha Kiran Yadav, Ch, S., & l, H. (2025). A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ASPIRIN AND PRASUGREL IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM. International Journal of Pharmacy and Analytical Research, 14(4), 1111–1127. Retrieved from https://ijpar.com/ijpar/article/view/1018

Issue

Vol. 14 No. 4 (2025): 2025 Volume - 14 Issue - 4

Section

Articles