ANALYTICAL METHOD VALIDATION FOR DETERMINATION OF RESIDUAL TRIETHYLAMINE CONTENT IN ERTAPENEM SODIUM BY HEAD SPACE GAS CHROMATOGRAPHY

ANALYTICAL METHOD VALIDATION FOR DETERMINATION OF RESIDUAL TRIETHYLAMINE CONTENT IN ERTAPENEM SODIUM BY HEAD SPACE GAS CHROMATOGRAPHY

Authors

  • D. Rakesh Arya college of Pharmacy, Kandi, Sangareddy, affiliated to Osmania University, Hyderabad, Telangana, India
  • Anjali Bharadwaj Arya college of Pharmacy, Kandi, Sangareddy, affiliated to Osmania University, Hyderabad, Telangana, India
  • Mohammad Omar Arya college of Pharmacy, Kandi, Sangareddy, affiliated to Osmania University, Hyderabad, Telangana, India

Keywords:

Triethylamine, Ertapenem Sodium, Validation, Gas Chromatography

Abstract

The analysis of residual organic solvent Triethylamine in Ertapenem Sodium, an active pharmaceutical ingredient was investigated. Ertapenem is used to treat certain serious infections, including pneumonia and urinary tract, skin, diabetic foot, gynecological, pelvic, and abdominal (stomach area) infections, that are caused by bacteria. The Headspace gas chromatography method described in this investigation utilized HP-5, 30 meter x 0.53 mm with 5.0 μm, FID detector. The injector temperature was set at 220ºC. Nitrogen was used as a carrier gas. The method was validated to be specific, linear, precise, sensitive, rugged and showed excellent recovery.

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Published

2025-12-05

How to Cite

D. Rakesh, Anjali Bharadwaj, & Mohammad Omar. (2025). ANALYTICAL METHOD VALIDATION FOR DETERMINATION OF RESIDUAL TRIETHYLAMINE CONTENT IN ERTAPENEM SODIUM BY HEAD SPACE GAS CHROMATOGRAPHY. International Journal of Pharmacy and Analytical Research, 14(4), 1241–1249. Retrieved from https://ijpar.com/ijpar/article/view/1031

Issue

Vol. 14 No. 4 (2025): 2025 Volume - 14 Issue - 4

Section

Articles