A Review on Method Development and Validation of Anticancer Drugs Pralsetanib and Azacitidine by Different Analytical Techniques

Abstract

Pharmaceutical analysis is a broader term which can be defined in many ways. It is the series of processes that are used for identification, determination, separation, purification, and structure elucidation of the given compound used in the formulation of pharmaceutical products. Recent development in analytical methods has been resulted from the advancement of analytical instruments. The improvement of the analytical method development and analytical instruments like UV, HPLC, LC-MS, GC are required for reduced the time of analysis, increased precision and accuracy and reduced costs of analysis. Pralsetinib is a RET receptor tyrosine kinase inhibitor for the treatment of metastatic RET-driven non-small cell lung cancer. Azacitidine is in a class of medications called demethylation agents. Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside present in DNA and RNA. It induces antineoplastic activity by inhibiting DNA methyl transferase at low doses and inducing cytotoxicity by incorporating itself into RNA and DNA at high doses.