Formulation Development and In Vitro Evaluation of Effervescent Floating Matrix Tablets of Rosuvastatin Calcium

Abstract

The present study aimed to develop effervescent floating matrix tablets of Rosuvastatin calcium using direct compression with sodium bicarbonate as a gas-generating agent and polymers including HPMC K100M, Carbopol 934P, guar gum, and xanthan gum. Tablets were evaluated for pre-compression parameters, physical properties, buoyancy, and in vitro drug release. Optimization was performed by varying polymer type and concentration. FT-IR analysis confirmed no significant drug–excipient interactions. The optimized formulation (F10) showed sustained drug release up to 24 h (99.65% cumulative release) with a floating time exceeding10 h. Drug release followed the Higuchi model (R² = 0.996) and exhibited a non-Fickian diffusion mechanism.