Formulation and evalaution of chlorzoxazone transdermal emulgel by using natural penetration enhancer
DOI:
https://doi.org/10.61096/ijpar.v8.iss1.2019.38-44Keywords:
Emulgel, Chlorzoxazone, Carbopol 940P, Span 20.Abstract
Emulgel is one of the recent technologies in NDDS used for dual control release of emulsion and gel for topical use. Gel formulations generally provide faster drug release compared with conventional ointments and creams. Chlorzoxazone is a well-known therapeutic agent that is used mainly for its skeletal muscle relaxants. The aim and objective of the study is to formulate Chlorzoxazone emulgel for topical application. Emulgel of Chlorzoxazone, consist of Carbopol-940 or HPMC K4 as a gelling agents for gel formulation and tween 80, span 20, for emulsion formulation. Emulgel was formulated by emulsion incorporated in gel. Chlorzoxazone loaded emulgel was formulated by using o/w emulsion because of lower solubility in water. Lemon grass oil, Menthol was used as a penetration enhancer in emulgel formulation. Optimized formulation was evaluated for physical examination, swelling index, skin irritation study, extrudability study, drug content determination, spreadability, globule size determination and invitro drug release, rheological study. Optimized formulation shown drug release 98.8%. for 12 hrs.