Formulation and evaluation of sustained release tablets of indinavir by using natural polymers

Abstract

The main objective of this research work was to formulate and evaluate of sustained release tablets of Indinavir by using natural polymers. It is having a short biological half-life (1.5 h) so it is considered as a suitable drug for the formulation of sustained release tablets to prolong its therapeutic action. Sustained release tablets were prepared by wet granulation technique, using synthetic and natural polymers at different ratios. Granules were prepared and evaluated for bulk density, tapped density, Hausner’s ratio, compressibility index. The Fourier-transform infrared spectra of the indinavir and different natural polymers alone show the compatibility of the drug with excipients. The physicochemical properties of tablets were found within the limits. The prepared tablets were evaluated for weight variation, thickness, hardness, % friability, % drug contents, and in vitro release. In vitro dissolution studies (USP dissolution rate test apparatus II, 50 rpm, 37°C ± 0.5°C) was carried out for the first 2 h in 0.1 N HCl (1.2 pH) and followed 6.8 phosphate buffer for 12 h as a dissolution medium. The optimized formulation F7 was shown maximum drug release 97.3±0.22% in 12 h of dissolution.