Sythesis and biological evolution of trizole derivatives

Abstract

1,2,4-Triazole derivatives have consistently attracted scientific and practical interest because of their widely varying chemical  properties, synthetic  versatility, and  pharmacological activities,  such  as  antibacterial, antifungal, anti tubercular,  analgesic,  anti-inflammatory,  anticancer,  anticonvulsant,  antiviral,  insecticidal,  and  antidepressant antiviral properties. Moreover, the 1,2,4-triazole compounds carrying sulfone moiety or imine bond have been reported as antibacterial and antifungal, antihypertensive, analgesic, anti-inflammatory, or anti tumoral agents. The synthsised triazole compounds 5-(4-nitrostyryl)-5-(benzylideneamino)-1, 2, 4-triazolidine-3-one, 5-(hydroxy styryl)-5-(benzylideneamino)-1,    2,    4-triazolidine-3-one were    biologically    evaluated    for antibacterial,    antifungal, antihelmintic activity. The synthsised triazole compounds shows good anti bacterial, anti fungal activity, against standard drugs like chloramphenicol, tetracycline, fluconazole. In the present study, as a part of our ongoing research, we designed and synthesized new hybrid molecules containing different pharmacophores in a single structure.