A new UV-spectrophotometric method for the determination of Ornidazole in bulk and in formulations using sodium citrate as hydrotropic solubilizing agent

Authors

  • K.Rajeswar Dutt Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana-508001
  • Rabha Hani Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana-508001
  • G.Yeshwanth Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana-508001
  • V.Bharani Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana-508001
  • Rayees Ahmed Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana-508001
  • G. Koteswar Rao Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana-508001
  • I.Santhosh Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana-508001
  • K.N.V. Rao. Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana-508001

Keywords:

Spectrophotometry, Hydrotropy, Ornidazole, Sodium citrate.

Abstract

A thorough literature survey of the various analytical methods for the quantitative estimation of Ornidazole in both bulk drug and dosage forms has revealed that very few analytical methods are available utilizing the hydrotropic solubilisation technique to date. The present research paper is a description n of a new analytical method developed using the principle of Hydrotropy employing very easily available chemical namely 0.75M Sodium citrate solution. The method has been validated as per ICH guidelines and found to conform to ICH guidelines. In the present investigation the use of organic solvent has been avoided due to their high cost, volatility and toxicity, making the method environmental friendly. The findings revealed that the method is new,  simple,  safe,  environmental  friendly,  accurate,  precise,  rep roducible  and  cost-effective.  It  can  be successfully employed as  a  routine  analytical procedure for  the  analysis of  Ornidazole tablets.  Hence  the authors suggest that this analytical method can be adopted in the Pharmaceutical industry for the analysis of Ornidazole in bulk and various dosage forms. Ornidazole shows its maximum absorbance at 303 nm and Beer’s law  was  obeyed  in  concentration  range  of  1 -5µg/ml  in  presence  of  0.75M  Sodium  citrate  and  Molar absorptivity. The statistical analytical parameters namely Correlation coefficient were computed and found to be, 0.950

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Published

2022-09-05